마우스 실험을 통해 프리온 감염에 있어서 나이(연령)에 따른 감수성의 차이를 연구한 논문입니다.
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Age-related alterations affect the susceptibility of mice to prion infection
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Age-related alterations affect the susceptibility of mice to prion infection
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Received 12 July 2009;
revised 10 December 2009;
accepted 21 December 2009.
Available online 31 December 2009.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-4Y29SSG-3&_user=10&_coverDate=12%2F31%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1454112623&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ae4e0902e4a5403eb5748b5a012c9c99&searchtype=a
- 1.
- Introduction
- 2.
- Materials and methods
- 2.1. Animal study
- 2.2. Histology and immunohistochemistry
- 2.3. Preparation of brain homogenates
- 2.4. Immunoblotting
- 2.5. Real-time PCR
- 2.6. Statistical analysis
- 2.2. Histology and immunohistochemistry
- 3.
- Results
- 3.1. Extended incubation time of prion disease in mice infected at old age
- 3.2. Milder neuropathology of prion disease in mice infected at older age
- 3.3. Decreased accumulation of PrPSc in the brains and spleens of aged mice
- 3.4. Elevated PrPC protein levels in the brains of normal aged mice
- 3.5. Spleens of aged and young naïve mice present comparable mRNA levels of tyrosine hydroxylase (TH)
- 3.6. The effect of age on the upregulation of disease-associated genes in response to prion infection
- 3.2. Milder neuropathology of prion disease in mice infected at older age
- 4.
- Discussion
