A review of emergency foot-and-mouth disease (FMD) vaccines

P.V. Barnett a, H. Carabin b,∗

a Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
b Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St-Mary’s Campus, London W2 1PG, UK

Received 6 August 2001; received in revised form 5 November 2001; accepted 27 November 2001

출처 : Vaccine 20 (2002) 1505–1514

Abstract

The primary objectives of this paper are to describe emergency foot-and-mouth disease (FMD) vaccines and review literature on
emergency vaccine efficacy to protect animals against (1) clinical signs and (2) infection (local virus replication). The reviewed experiments
suggest that in cattle, sheep and pigs, the vaccine could be effective in preventing disease within 4–5 days post-vaccination. These studies
also suggest that the risk of spreading infection decreases as the interval between vaccine and challenge increases and that vaccination could
reduce the amount of virus excreted compared to non-vaccinated animals. We suggest areas of future research to improve our knowledge
of emergency vaccines. © 2002 Elsevier Science Ltd. All rights reserved.
Keywords: Foot-and-mouth disease; Vaccine; Virus